I won't ask you to reconsider your choice of VB.net but I'm well known (at least on the Programmers Oracle) for my extreme dislike of VB and BASIC in general. This is mostly due to my C64 days (which introduced me to BASIC) up to me VB6, macro and ASP based work with it (it's endless list of required DLL's for older versions of Windows didn't help either!).
PInvoke is good for VB.NET and .net languages in general. And, although the Nux and Nix heads in the population will tell you it's all rubbish and that Python is the king, they'll be sadly mistaken. Even more so, if they try and claim that it's actually a VHL language.
Ok... My childish qualms aside, lets see if I can help. I've got an hour before I need to leave for a haircut (it's 15:15 right now). If you can reply in enough time before then, then I should be able to help you today.
VB's process memory API's are generally ok and although I haven't written any programs which impliment them, there is plenty of info on the net regarding it. A lot of game development is done using VB and VB.net (mainly due to older lecturers still including it as a viable language). It's so popular in fact that, if you type readprocessmemory into Google, you're 90% certain to find a game dev related link within the first ten page results.
http://www.gamedev.net can help you a LOT more with that than I could.
What specifically do you want help with?
I can point you in the direction of places and what tools to look for but seeing as this is a programming question regarding pointers and help, it might be better suited to be in the Programmers Oracle (
http://community.sigames.com/eve/ubb...rm/f/893197497) where members of SI post regularly. This forum is generally for the announcement of editors, bugs and other stuff that lower level users (people who just want to use the editor rather than discuss the inner workings of the readprocessmemory) would be.
If you wish to continue this discussion there as a new topic (perhaps referencing this one) then you're highly likely to get a good all round opinion from others and also the people who wrote the game in the first place!