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No.
(Apart from the time it takes the game to start up, but turning on the skin cache reduces this time, you just need to turn the skin cache off whenever you want to add more graphics).
I actually think it does increase load time, not match speed or processing speed though. A fresh, out-of-the-box FM loads way faster than an FM with multiple graphics installed.
The only thing extra graphics (and complicated skins) slow down is the time taken for the first screen to appear after you have double click the shortcut (this is also affected by how long it takes for your cd drive to start up and for the copy protection to check you have the disk in). Graphics don't slow anything down after the first license screen. (If the game has a problem loading the graphics, it'll load the graphic after the page, but doesn't slow down the loading of the page.)
Turning on the skin cache reduces the time it takes for the first screen to appear after you have double clicked the shortcut (as it's not scanning all the config files for a change in the file).