Two quick thoughts of mine. First, on the Rule of Two/Global Mentality split. I've been trying to capture the best of both worlds by having wingers without farrows and fullbacks set to the same mentality, and everything else arrayed pretty much as it is in the RoT. With a reasonably pacy and smart fullback (Srna) set to run forward often, I've been getting some good overlaps. With Bouma on the other side, I've dialed forward runs down to "rarely," with the result that he usually manages to chug up into a supporting position.
Now for target men. I've employed two different ones at Villa: Angel and Agbonlahor. Angel is who I use in my standard system, and I like to keep him in the center of the park by giving him a pretty low CF. With a moderately attacking mentality, he lays off the ball to Petrov at AMC, or tries to play the ball wide to the other pacy striker (who has CF around 18, or even a free role occasionally if the opponent's back four is slow.)
I like to use Gabby as a target man in the counter-attacking system set out so well by wwfan above. With a sarrow moving him into a channel and high CF, plus a "run onto ball" instruction, passing at 15, and direction to play down one flank, he gets lots and lots of breaks down the line. Eventually the AI catches on and keeps the fullback back, so I go to a mirror formation, which works for a little while too.