Definately. In Spain I play a 3-2-3-1-2. This works great because I've got good wingers and a solid central defence. In Spain they tend to have attacking fullbacks, so my wigners get in easily, and attack through the middle rather than the wings. I won the league with Betis and had great success domestically with that tactic and without buying many differentp layers.
However, I then went to Roma in Italy and tried the same tactic only for us to be stuffed by any half decent side. They use the wings more and have good defenders down the wings, not just attacking fullbacks (or to more of an extent anyway). This meant my defence was too narrow and opposition teams got in behind down the flanks and scored from crosses and I couldn't break down teams as easily as my whole game revolved around finding the width the teams in Spain just didn't have.
IMO Spain is definately the easiest of the "big 3" domestic leagues as all the sides are very similar style - in England you could play Arsenal and then Bolton - two totally different teams who you have to alter your own game to play against.