Few things ..
First of all, if you have dual core, HT or SMP make sure threading is ticked in preferences.
Next up, assuming you have 1gb + ram its OK to select every league as playable, but you must go to the options > detail level menu and set every league you ARENT playing in to NONE.
Cup, internationals etc you can set to Later Stages or if you are playing in it, ALL
That should result in a plenty fast game.
PS: Load additional players from the main footballing nations e.g. England, Brazil, France, Germany, Portugal, Holland, Italy + maybe 2-3 more is also recommended.
Don't go mental, adjust the detail level and it will be fine.
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