Well, you would want to kill the game. Increase the time wasting. I usually max it out after 80th min. Sometimes even earlier
Adopt slow tempo. This will help you keep possession. You may try short passing as well if to increase the effect but it may result in the opposition closing down on you and steal the ball in your half - so be careful with this setting.
You may abandon counter attacks in later stages of the game if the opposition is denying you chances anyway. However, if your CAs are dangerous you should leave them as one more goal will never do harm
Try reducing closing down settings. This may be dangerous as you allow the opposition more possession. On the other side your players stay in position and deny space.
You may sub one striker for a defensive player. I play 442 but often end the game with 541. You can use an extra defender to mark the opposition danger man. Or simply use him as a third DC. Or put him as DMC to intercept passes, or manmark the opposition playmaker.
You can assign more players to stay back at attacking set pieces.
If the opposition plays 424 consider the following settings:
- set your full backs like your DCs - no FWR, no RWB, low CFreedom, low mentality, etc.
- try to keep possession in the middle with slow tempo and short passing...
Also, sub tired players and players with no defensive skills. In the last minutes of a game you have the lead you would like to have a player like Drogba or scholes rather than player like right-phillips or ronaldo. You need good, aggressive tacklers, high jumpers, etc. dribbling, creativity and flair are no longer desired attributes in your squad. Go for teamwork, work rate...