Sky please don't be impatient. A lot of folks either haven't the immediate time to get to the forum or they can't help. And it wouldn't be of any use for everyone who reads the thread to post a reply just to say they can't offer any help for the problem.
You've been here awhile, i'm sure you know exactly how things work here.
I've never seen/heard of this problem either and so don't really have much to offer other then deleting the Prefs 'file' (not 'folder' as you stated), or... double checking to make sure you're always in RGB mode when trying to use those tools. Keep in mind that only a select few IMAGE Modes allow full use of all tools in the Toolbar. Other modes only have a limited toolbar to work with.
Next time this happens, open the IMAGE menu and choose MODE>RGB. Or make sure that RGB is currently selected.
If being in RGB mode is NOT the problem, then i highly suggest you go back to Adobe and demand they help you. After all, that's what we're paying for right? The company to support their product. And if it's not working as it should, then it's on them to help you figure out why, and provide alternatives for you if they cannot help you.