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I've saved a high res psd (300dpi) as pdf. I flattened the image before PDFing and used a JPG compression of 10. If I open the pdf from a browser, the browser version of acrobat does strange things to the image. Looks great until you scroll, then the image and text become very edgy jaggy. BUT, if I open acrobat and open the pdf, it looks great. Has it something to do with the browser version of acrobat? Is there some PDF preference or option that I'm missing?
photoshop pdf's are notoriously bad for pre-press, in fact pitstop even warns you if your're dealing with one. The same may be true for screen. Maybe you should save as an eps, and distill to pdf.