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Ray Stubbs presents highlights and goals from the day's Premier League fixtures in Saturday's Match of the Day (2230 GMT, BBC ONE/online and Sunday 0745 GMT on BBC ONE/online).
Paul Jewell's Derby will hope to cause one of the shocks of the season when they head to Old Trafford to face champions Manchester United.
The Rams have struggled in the top flight since winning promotion via the play-offs, losing 6-0 at Liverpool and 5-0 at Arsenal.
With Wayne Rooney and Carlos Tevez in scintillating form, Derby keeper Stephen Bywater could be in for a busy afternoon.
Former Red Devils favourite Roy Keane leads his Sunderland side out against Chelsea, with the Black Cats looking to avoid a sixth successive defeat against the Blues.
At the Madejski Stadium Reading go in search of their first ever win against Liverpool, while Everton take on Fulham, Newcastle play Birmingham and Aston Villa host Portsmouth
MOTD RUNNING ORDER*
Aston Villa v Portsmouth
Newcastle v Birmingham
Reading v Liverpool
Man Utd v Derby
Everton v Fulham
Chelsea v Sunderland
*Subject to change