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Gary Lineker presents highlights and goals from the day's Premier League fixtures in Saturday's Match of the Day.
Defending champions Manchester United host bogey side Middlesbrough, who are unbeaten in their last four league visits to Old Trafford.
Visiting manager Gareth Southgate was in the Middlesbrough team the last time they emerged pointless from this fixture five years ago.
Avram Grant will be looking for his first home league win as Chelsea boss, with Manchester City the visitors.
While Chelsea have endured a tumultuous start to the season, City have surpassed expectations under Sven-Goran Eriksson, with Brazilian playmaker Elano the fulcrum of their attack and Micah Richards imperious in defence.
In other games, two of the three promoted clubs are in action - Birmingham face Wigan and Sunderland host fellow strugglers Fulham.
Tonight's MOTD running order
Chelsea v Man City
Man Utd v Middlesbrough
Portsmouth v West Ham
Birmingham v Wigan
Reading v Newcastle
Sunderland v Fulham
Originally posted by Tim Madisun:
I think I'm going to be briefly pictured at the Reading game, after *something* happens. Good game, from a neutral's point of view.