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On Sunday, Adrian Chiles introduces highlights of the day's fixtures, plus a review of Saturday's action, in Match of the Day 2 (2200 GMT, BBC TWO/online).
Tottenham's last two visits to West Ham have produced real drama.
In May 2006, a Tottenham side weakened by food poisoning slumped to a 2-1 defeat, which allowed arch-rivals Arsenal to claim the final Champions League spot
Last season Spurs came from 2-0 down to win 4-3, thanks to last-gasp goals from Dimitar Berbatov and Paul Stalteri.
The day's other Premier League game sees Fulham play Blackburn at Craven Cottage.
In last season's encounter, the hosts held off sustained Rovers pressure to edge a point, which proved vital in their successful battle to avoid relegation.
Yet early season form suggests Fulham will be facing another tough fight to preserve their top flight status.
Adrian is joined in the studio by Gavin Peacock and Paul Jewell.