I'm into my fourth season, after winning the Serie B, Serie A twice and Champions League (What a game!) but to be honest struggling a bit.
The Current team I use is:
GK: Buffon
DR: Rafinha
DL: Chiellini
DC: Vanden Borre/Digard
DC: Albiol
MC: Richards/Lucas
MR: Cardenas/Camoranesi (cant spell

)
ML: Guardado
AMC: Vela/Chiumiento
FC: Bojinov/Bendtner
FC: Klose/Vucinic
Ive got some really good backup players, people such as Diarra, Aythami, Souza (looks brilliant already) Ambrosino (looks to be world class in a few years). The team looks strong, I normally get more shots than the other team from decent positions (they always hit it right at the keeper..) great strikers, good midfield, and probably a bit young defence, nevertheless I always concede a few goals and im not sure what to do now. I play a 4-3-1-2 that has worked for many years, which is a tactic I made but maybe it has been broken now I am not sure.
I recommend the following players, you may have/may not have heard of them:
Bojinov
Cardenas
Guardado
Digard
Bendtner
Lucas
Guys...if you dont already, USE CHIUMIENTO HE IS REALLY GOOD, his stats arent the best but by god he does well for me!
I got some other youngsters including Torre, Merida, Djuric, Defour, but a few of them arent progressing that well.